Genetic Modeling of Abnormal Photosensitivity in Families with Polymorphic Light Eruption and Actinic Prurigo
نویسندگان
چکیده
منابع مشابه
Treatment of polymorphic light eruption.
Polymorphic light eruption (PLE) is a highly prevalent photosensitivity disorder, estimated to affect 11-21% people in temperate countries. Typically, PLE appears as a recurrent pruritic eruption comprising papules and/or vesicles and/or plaques, which occurs on photo-exposed skin sites following sun exposure, and which heals without scarring. Commoner in females, the aetiology is uncertain, al...
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Actinic prurigo is a rare disease occurring mainly in individuals of American Indian origin and those living in high altitudes. Skin lesions consist of pruritic popular or nodular excoriated lesions mainly affecting exposed skin but covered skin is also involved in up to 50% of patients. This is the first case report of an Iranian patient. This 19-year-old female had pruritic popular and ...
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Polymorphic light eruption is one of the few dermatological diseases in which some antioxidants have been said to be reduced in both the epidermis and the blood. This study measured the hydrosoluble antioxidant capacity in the serum of patients with polymorphic light eruption, using a commercially available kit. All patients were tested in winter, in order to avoid the influence of exposure to ...
متن کاملAdhesion molecule expression in polymorphic light eruption.
Endothelial leukocyte adhesion molecule-1 (ELAM-1), vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) are cytokine-regulated cell-surface leukocyte adhesion molecules. We have investigated the in vivo kinetics and pattern of expression of these adhesion molecules in relation to tissue accumulation of leukocytes in the photodermatosis, polymorphic light e...
متن کاملPathogenic mechanisms of polymorphic light eruption.
Polymorphic light eruption (PLE) is a photodermatosis (i.e. "sun allergy") with a high prevalence, particularly among young women in temperate climates. It is characterized through itchy skin lesions of variable morphology, occurring in spring or early summer on sun exposed body sites. As yet the exact etiology and pathogenesis of PLE are unknown although a resistance to ultraviolet (UV)-radiat...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2000
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2000.00080.x